PESTICIDES AND THE VASCULAR SYSTEM: A HIDDEN LINK
DOI:
https://doi.org/10.56238/revgeov17n1-177Keywords:
Pesticides, Health, Vascular System, BrazilAbstract
Brazil is one of the world's leading agricultural producers, but unfortunately, our country ranks first in pesticide consumption. Because pesticides have serious impacts on human health, their use should be considered a silent public health emergency. Therefore, this integrative review will address the repercussions of pesticides on human health, with an emphasis on the vascular system.
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Atkinson JE, Bolte HF, Rubin LF, Sonawane M. Assessment of ocular toxicity in dogs during 6 months' exposure to a potent organophosphate. J Appl Toxicol, 14, p.145-52, 1994.
Berry C, Sidik N, Pereira AC, et al. Small-Vessel disease in the heart and brain: Current knowledge, unmet therapeutic need, and future directions. J Am Heart Assoc, 8, p.e011104, 2019.
Botnaru AA, Lupu A, Morariu PC, et al. J Neurotoxic effects of pesticides: Implications for neurodegenerative and neurobehavioral disorders. J Xenobiot, 15, p.83, 2025.
Coleman B, Asad I, Heng YY, Menard L, Were FH, Thomas MR, Karr CJ, McHenry MS. Pesticides and neurodevelopment of children in low and middle-income countries: A systematic review. PLoS One, 20,p.e0324375, 2025.
Damalas CA, Koutroubas SD. Farmers' exposure to pesticides: toxicity types and ways of prevention. Toxics,4,p.1, 2016.
FAO, IFAD, UNICEF, WFP and WHO. 2023. The State of Food Security and Nutrition in the World 2025. https://www.fao.org/publications/fao-flagship-publications/the-state-of-food-security-and-nutrition-in-the-world/en. Acessado: 09/12/2025
Figueiredo TM, Santana JDM, Granzotto FHB, et al. Pesticide contamination of lactating mothers' milk in Latin America: a systematic review. Rev Saude Publica, 58, p.19, 2024.
Finsterer J, Beltramim L, Bombardi LM, de Almeida AG, Scorza FA. Keep your eyes healthy: eat organic food. Nutr Rev, 83, p:e738-e39, 2025.
Fortes C, Mastroeni S, Melchi F, et al. The association between residential pesticide use and cutaneous melanoma. Eur J Cancer, 43, p.1066–75, 2007.
Fucic A, Duca RC, Galea KS, et al. Reproductive health risks associated with occupational and environmental exposure to pesticides. Int J Environ Res Public Health, 18, p.6576, 2021.
Giambò F, Teodoro M, Costa C, Fenga C. Toxicology and Microbiota: How do pesticides influence Gut Microbiota? A review. Int J Environ Res Public Health, 18, p.5510, 2021.
Gomez-Delgado F, Raya-Cruz M, Romero-Cabrera JL, Perez-Martinez P. Environmental pollution and cardiovascular health. Challenges and new perspectives. Clin Investig Arterioscler, 8,p.500802, 2025.
Hankey GJ. Vascular disease of the heart, brain and limbs: new insights into a looming epidemic. Lancet, 366, p.1753-4, 2005.
Hess SC, Nodari R. Agrotóxicos no Brasil: panorama dos produtos entre 2019 e 2022. Ambientes em Movimento, 2, p.39-52, 2022.
Ichikawa H. Neurotoxicology of pesticides. Brain Nerve, 67,p.39-48, 2015.
Jaga K, Dharmani C. Ocular toxicity from pesticide exposure: A recent review. Environ Health Prev Med, 11,p.102-7, 2006.
Kim KH, Kabir E, Jahan SA. Exposure to pesticides and the associated human health effects. Sci Total Environ, 575, p.525-35, 2017. http://doi.org/10.1016/j.scitotenv.2016.09.009.
Kós MI, Hoshino AC, Asmus CI, Mendonça R, Meyer A. Peripheral and central auditory effects of pesticide exposure: a systematic review. Cad Saude Publica, 29, p.1491-506, 2013.
Lucero B, Muñoz-Quezada MT. Neurobehavioral, neuromotor, and neurocognitive effects in agricultural workers and their children exposed to pyrethroid pesticides: A review. Front Hum Neurosci, 15, p.648171, 2021.
Marshall NE, Abrams B, Barbour LA, et al. The importance of nutrition in pregnancy and lactation: lifelong consequences. Am J Obstet Gynecol, 226, p.607-32, 2022
Mie A, Andersen HR, Gunnarsson S, et al. . Human health implications of organic food and organic agriculture: a comprehensive review. Environ Health, 16,p.111, 2017.
Mnif W, Hassine AI, Bouaziz A, Bartegi A, Thomas O, Roig B. Effect of endocrine disruptor pesticides: a review. Int J Environ Res Public Health, 8, p.2265-303, 2011.
Mowafi S, Dabbish AM, Chukwuma CC, Adel L, Abdelnaser A. Toxic sprays, fragile brains: assessing pesticides exposure and disparities on neurodevelopment. Neuroscience, 579, p.344-54, 2025
Pandiselvam R, Kaavya R, Khanashyam AC, et al. Research trends and emerging physical processing technologies in mitigation of pesticide residues on various food products. Environ Sci Pollut Res Int, 29, p.45131-49, 2022
Pluth TB, Zanini LAG, Battisti IDE. Pesticide exposure and cancer: an integrative literature review. Saúde Debate, 43, p.906-24, 2019.
Rigotto RM, Vasconcelos DP, Rocha MM. Pesticide use in Brazil and problems for public health. Cad Saude Publica, 30, p.1360-62, 2014.
Román P, Ruiz-González C, Rueda-Ruzafa L, Cardona D, Requena M, Alarcón R. Exposure to environmental pesticides and the risk of Autism Spectrum Disorders: A population-based case-control study. Medicina, 60, p.479, 2024.
Scorza FA, Beltramim L, Bombardi LM. Pesticide exposure and human health: Toxic legacy. Clinics, 78, p. 100249, 2023.
Scorza FA, Bombardi LM, Beltramim L. Agrotóxicos e a Saúde Humana. In: Scorza FA, Bombardi LM, Beltramim L, editors. Agrotóxicos e a Saúde Humana. Brasil: Editora dos Editores, p. 1-76. ISBN-10. 6561030451
Scorza FA, de Almeida AG, Scorza CA, Fiorini AC, Finsterer J. The microbiota in Parkinson's disease: Natural products to help our clinical practice. Pharmacol Res, 175, p.105984, 2022.
Scorza FA, Finsterer J, Wuo-Silva R, Chaddad-Neto F. Pesticides in food: implications for menopausal women. Arch Gynecol Obstet, 310, p.2749-50, 2024.
Sekhotha MM, Monyeki KD, Sibuyi ME. Exposure to agrochemicals and cardiovascular disease: A review. Int J Environ Res Public Health,13,p.229, 2016.
Sharma T, Sirpu Natesh N, Pothuraju R, Batra SK, Rachagani S. Gut microbiota: a non-target victim of pesticide-induced toxicity. Gut Microbes, 15, p.2187578, 2023.
Spiewak R. Pesticides as a cause of occupational skin diseases in farmers. Ann Agric Environ Med, 8, p.1-5, 2001.
Tarmure S, Alexescu TG, Orasan O, et al. Influence of pesticides on respiratory pathology- a literature review. Ann Agric Environ Med, 27,p.194-200, 2020.
Terreros G, Cifuentes-Cabello C, D'Espessailles A, Munoz F. Impact of pesticide exposure on auditory health: Mechanisms, efferent system disruption, and public health implications. Toxicology, ;512, p.154071, 2025.
Tessari L, Angriman M, Díaz-Román A, Zhang J, Conca A, Cortese S. Association Between Exposure to Pesticides and ADHD or Autism Spectrum Disorder: A Systematic Review of the Literature. J Atten Disord, 26, p.48-71, 2022.
Treviño MJS, Pereira-Coelho M, López AGR, et al. How pesticides affect neonates? - Exposure, health implications and determination of metabolites. Sci Total Environ, 856, p.158859, 2023.
Utembe W, Kamng'ona AW. Gut microbiota-mediated pesticide toxicity in humans: Methodological issues and challenges in the risk assessment of pesticides. Chemosphere, 271, P.129817, 2021.
Watanabe Ma,de Abreu LS, Luiz AJB. The fallacy of organic and conventional fruit and vegetable prices in the metropolitan region of campinas, São Paulo, Brazil. J. Asian Rur. Stud.4,p.1-22, 2020.
Wu X, Wei D, Zhou Y, Cao Q, Han G, Han E, Chen Z, Guo Y, Huo W, Wang C, Huang S, Zeng X, Wang X, Mao Z. Pesticide exposures and 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis. J Hazard Mater, 485,p.136835, 2025.
Ye M, Beach J, Martin JW, Senthilselvan A. Pesticide exposures and respiratory health in general populations. J Environ Sci, 51, p.361-70, 2017.
Zago AM, Faria NMX, Fávero JL, Meucci RD, Woskie S, Fassa AG. Pesticide exposure and risk of cardiovascular disease: A systematic review. Glob Public Health, 17, p.3944-66, 2022.
Zanchi MM, Marins K, Zamoner A. Could pesticide exposure be implicated in the high incidence rates of depression, anxiety and suicide in farmers? A systematic review. Environ Pollut, 331, p.121888, 2023.
Zyriax BC, Windler E. Lifestyle changes to prevent cardio- and cerebrovascular disease at midlife: A systematic review. Maturitas,167, p.60-5, 2023.
